Centralized Capture & Processing of CNS Clinical Trial Data
Your trial relies on accurate data to detect treatment effects. But when data are collected and reported inconsistently across multiple investigator sites, variability increases — making it harder to separate signal from noise.
Your pathway to clear, actionable data starts with centralized data capture and processing from Clinilabs’ Corelabs.
Your Turnkey Corelabs
Clinilabs’ Corelabs data services centralize data capture and processing with industry-leading operational expertise, physical and electronic security systems, and high-performance network infrastructure fully equipped with:
- Project management & certification
- Dedicated PMs and support teams
- Investigator site qualification
- Site certification, including equipment, staff, and scoring standards
- Certification approval before study start
- 24/7 support
- Expert data processing
- Team includes RPSGTs, M.D.s, and Ph.D.s with 450+ years of combined experience
- Monthly quality meetings and rigorous training
- 10% of studies benchmarked for inter-rater reliability
- Rapid turnaround times
- Quality assurance
- Scoring follows AASM standards and protocol-specific rules
- Each file undergoes multilevel QC and is rated for data and documentation quality
- Device management
- Study-wide SOPs
- Study life cycle support
- From site feasibility to final data transfer
- Custom Site Operations Manuals and training materials
- Regular progress reporting and metrics tracking
Our platform connects investigator sites and sponsors around the world to a validated and secure Corelabs data services center housed in the United States. Hosting data from seven core laboratories strategically placed worldwide, it efficiently and accurately aggregates and processes data from multicenter clinical trials.
Failed trials have been successfully repeated using our Corelabs. Let us put you on the pathway to CNS approval.
Your CNS Corelabs Data Experts
As the CNS CRO, we have the indication-level expertise to provide data types.
Polysomnography (PSG)
Clinilabs is the world’s leading provider of centralized PSG as well as home sleep testing (HST), multiple sleep latency (MSLT), and maintenance of wakefulness test (MWT) data management.
We work with over 500 PSG investigator sites worldwide to offer our clients expert site selection, site training, site certification, and centralized PSG reading.
With more than 150 multicenter trials under our belts, our PSG Corelabs personnel are adept at processing data obtained in studies of:
- Insomnia
- Restless leg syndrome
- Obstructive and central sleep apnea
- Narcolepsy
- Circadian rhythm disorders
- And more
Electroencephalography (EEG)
Our team of experienced neuroscientists, data analysts, and engineers uses the latest EEG hardware and software to capture and analyze data from single-center and multicenter clinical trials, efficiently and compliantly delivering insight-ready output.
We pioneered standardization in EEG processing more than 20 years ago and have provided trusted data to our customers ever since. While standardization is the foundation of everything we do, we always offer customized solutions to meet the needs of each project.
Our EEG services include:
- Data acquisition
- Investigator site selection
- Instrumentation options that meet current industry standards
- Comprehensive data collection manuals, tailored to clinical trial protocols
- Conventional and high-resolution EEG recording methodologies
- In-laboratory and wearable setup options
- Data processing
- Processing by highly skilled technicians and board-certified epileptologists for seizure detection
- Artifact removal, signal filtering, and normalization
- Data segmentation
- Advanced signal analysis
- Time-frequency analysis
- Source localization
- Predictive modeling
- Report generation
- Detailed visual and statistical reports
- Customized insights based on your research goals
- Interactive data visualization tools
Quantitative Electroencephalography (qEEG)
Our expert qEEG team delivers sophisticated analyses of brain electrical activity through power spectral analysis and quantification of relevant qEEG bandwidths, delivering objective, quantifiable data on brain function that represent unparalleled value as biomarkers of brain and drug activity.
Applications for qEEG biomarkers include:
- Baseline measurement and longitudinal monitoring
- Exploration of kinetic-dynamic relationships
- Prediction of drug response
- Safety monitoring
Electrocardiography (ECG)
Cardiac safety assessment is essential for the development of neurotherapeutics, as many CNS therapies can produce impairments in cardiac conduction that often lead to serious adverse events such as fainting, cardiac arrest, and sudden cardiac death.
Clinilabs’ Corelabs collects and processes ECG using state-of-the-art instrumentation and time-tested standardized methods, resulting in datasets that can be used to assess cardiac safety with confidence. We also support routine safety ECGs, intensive Holter monitoring, and thorough QT studies.
Actigraphy and Psychomotor Vigilance Testing (PVT)
Combining the best in wearable actigraphy technology with expert Corelabs data management, we are the industry standard for integrating actigraphy output into large clinical datasets to assess:
- Sleep
- Wakefulness
- Activity levels
- Circadian rhythms
- And more
Some of the wearable devices we employ can also measure skin surface temperature, respiration, or environmental light. Many support built-in electronic patient reported outcomes (ePRO), ecological momentary assessments (eEMA), and psychomotor vigilance tests (PVT).
Wearable device application areas include:
- Sleep disorders
- Circadian rhythm disorders (e.g., shift work disorder, jet lag)
- Movement disorders
- Fatigue
- Alzheimer’s disease agitation
- Attention deficit hyperactivity disorder
- Depression and treatment-resistant depression
- Pain
Electromyography (EMG)
EMG and nerve conduction studies are used to evaluate muscle activity, muscle weakness, muscle wasting, and sensory symptoms. These assessments may be required in multicenter clinical trials for patients with movement disorders or conditions that affect the neuromuscular system.
Clinilabs’ EMG Corelabs collects and processes EMG signals using standardized methods that deliver data consistency and accuracy.
Video Ratings
There is significant variability in subject ratings in CNS clinical trials. By collecting videos of investigator ratings and overscoring them, our centralized video services minimize variance so you can better detect differences between treatment conditions in multicenter clinical trials.
What Will You Do With Your Corelabs Data?
From electronic case report forms to biostatistics and more, Clinilabs offers tailored clinical trial data services to put your product on the path to CNS approval.
Let the CRO for CNS Manage Your Phase 2-3 Trial
Multicenter clinical trials have complexities and challenges beyond data capture and processes. We offer comprehensive multicenter trial management services that put your trial on a streamlined path forward.
