Mike Detke, MD, PhD is a board-certified Psychiatrist, drug development scientist, and executive with over 25 years of research and leadership experience working within the biotech and pharmaceutical sectors. Experienced across numerous CNS diseases and all phases of development, including many INDs and NDAs, he is a data-driven, high-integrity, transparent communicator and leader who always puts people first. His expertise spans clinical trial sites, large pharma, several biotechs, vendor companies, as well as private and publicly held companies.

He is the founder and president of Detke Biopharma Consulting LLC, where he consults pharma, biotech, and NIH regarding CNS drug development and business strategy, mostly in C-level leadership roles. He provides medical leadership on clinical development, clinical trial design and conduct, regulatory documents such as INDs and Fast-Track applications, and at FDA meetings.

Dr. Detke has an impressive resume spanning a spectrum of diseases and disorders including:

• CMO at Cortexyme and later at Lighthouse where he led the clinical development of multiple assets for the treatment of dementia and other degenerative disorders.
• CMO at Embera NeuroTherapeutics where he was in charge of the clinical development of a novel combination drug via the 505-(b)(2) pathway, for the treatment of multiple addictions.
• CMO at CoMentis where he oversaw the clinical development of alpha7 ligands for Alzheimer’s disease and other cognitive disorders.
• CMO MedAvante where he led a team improving signal detection in CNS clinical trials.
• Executive Director for Neuroscience at Eli Lilly where he was responsible for all CNS assets in early phase development (Psychiatry, Neurology, Pain and Addiction).
• Senior Medical Director at Eli Lilly where he managed the global Phase 3 development for Cymbalta ($5B peak sales) and Phase 4 for Prozac.
• Clinical Research Physician at Eli Lilly where he oversaw clinical trials on r-fluoxetine and Cymbalta.

Dr. Detke graduated summa cum laude with a BA and MS in Psychology at Yale University and received his MA, MD, and PhD from the University of Pennsylvania. He continued his education as a Psychiatry Residency at Harvard Medical School, Massachusetts General Hospital, and McLean.

Since 2000, he has taught and supervised medical students and residents in patient care as an Adjunct Clinical (Full) Professor of Psychiatry at Indiana University School of Medicine.

Dr. Detke has over 70 published manuscripts in peer-reviewed journals, has served as a reviewer for numerous journals, and is an active member of selective scientific organizations such as ACNP, ASCP, ISCTM, and SOBP and is an experienced NIH grant review and recipient of $1M in NIH grants.

< Back to Team